Objective To observe the clinical effects of Jianpi Rougan Fang combined with Tegafur Gimeracil Oteracil Potassium capsule in the treatment of 30 patients with primary hepatic carcinoma in the middle and advanced stage. Methods Fifty-five patients with primary hepatic carcinoma in the middle and advanced stage were divided into the control group（ 25 cases） and the treatment group（ 30 cases）. Both groups took Tegafur Gimeracil Oteracil Potassium capsule for chemotherapy. The treatment group also took modified Jianpi Rougan Fang

one dose daily.Twenty-one days were considered as a treatment course

and both groups were given four treatment courses in all.Scores of Chinese medical symptom

quality of life

and size of hepatic tumors in two groups were compared before and after the treatment. The clinical effects

curative effects of Chinese medical symptom

quality of life

and toxic and side effects were evaluated after the treatment. The survival situation within one year after the treatment was also followed-up. Results The objective response rate of clinical effects and the clinical beneficial rate were 30. 00%and 83. 33% in the treatment group

but 28. 00% and 76. 00% in the control group

respectively

with no significant difference between the two groups（ P > 0. 05）. In the treatment group

the total effective rates of curative effects of Chinese medical symptom and quality of life were significantly higher than those in the control group（ P < 0. 05）. After the treatment

scores of symptoms in the treatment group were significantly lower than those before the treatment（ P < 0. 05）. After the treatment

scores of poor appetite

fatigue

abdominal distension and loose stool in the treatment group were significantly lower than those in the control group（ P < 0. 05）. After the treatment in both groups

KPS score were significantly higher and the tumor size significantly decreased than those before the treatment（ P <0. 05）. After the treatment

score of the quality of life in the treatment group was significantly higher than that in the control group（ P < 0. 05）. In the treatment group

cases with leukopenia

thrombocytopenia

stomatitis

and peripheral neurovirulence were significantly less than those in the control group（ P < 0. 05）. There was statistically significant difference in survival curve between the two groups（ P < 0. 05）. Conclusion Jianpi Rougan Fang combined with Tegafur Gimeracil Oteracil Potassium capsule may improve clinical symptoms and quality of life

reduce toxic and side effects of chemotherapy

and prolong survival time of patients with primary hepatic carcinoma in the middle and advanced stage.