Objective To observe the clinical curative effect of acupuncture with antidepressant in the treatment of adolescent depressive disorder. Methods Forty-six cases of adolescent depressive patients were randomly divided into the treatment group and the control group

with 23 cases in each. Both groups took antidepressant orally

and the treatment group was added with acupuncture treatment

once every other day. Fifteen times were taken as one treatment course

and the treatment group was given 3 courses of treatment in all. Scores of Hamilton Depression Scale（ HAMD） and Rating Scale for Side Effects（ SERS） of two groups were compared before and after treatment

as well as at follow-up visits 3 and 6 months later. Clinical curative effects and curative effects of antidepressant dose were evaluated. Results Comparison of curative effects in two groups: The recovery rate and total effective rate were26. 09% and 86. 96% in the treatment group

and 13. 04% and 78. 26% in the control group

respectively. The recovery rate and total effective rate in the treatment group was remarkably superior to those in the control group（ P <0. 05）. Comparison of dose effect of antidepressant in two groups: The efficiency rate and total effective rate were43. 48% and 82. 61% in the treatment group

and 13. 04% and 43. 48% in the control group

respectively. The total effective rate and efficiency rate in the treatment group was remarkably superior to that in the control group（ P <0. 05）. Scores of HAMD and SERS in the treatment group remarkably decreased after treatment

and at the 3rd month and 6th month follow-up visits compared with that before treatment（ P < 0. 05）. Scores of HAMD in the control group after treatment and at the 3rd month follow-up visit remarkably decreased compared with that before treatment（ P <0. 05）; There was statistically significant difference in HAMD scores between after treatment and the 6th month follow-up visit（ P < 0. 05）. Scores of HAMD and SERS in the treatment group after treatment

and the 3rd and 6th month follow-up visits were all lower than that in the control group at the same time points

respectively（ P < 0. 05）.Conclusion Acupuncture could effectively reduce the side reactions of antidepressant

decrease application dose of antidepressant

and have steady long-term curative effects on controlling adolescent depressive disorder.