Objective To evaluate the effect and safety of Houpo Paiqi Mixture（ 厚朴排气合剂） treating postoperative gastrointestinal motility disorders. Methods Reviewed all published literature from Pub Med

EMBASE

Cochrane Library

Web of Knowledge

Chinese Science Citation Database

China National Knowledge Infrastructure

VIP Data and Wan Fang Data

from the establishment of the databases to March of 2015. The randomized controlled trials of Houpo Paiqi Mixture treating types of disorders of gastrointestinal motility after operation were included. Two reviewers screened the papers

extracted data and evaluated papers quality independently. Made Meta analysis on the primary outcome index（ the first flatus time after operation） and the secondary outcome indexes（ the first defecation time after operation and the recovery time of borborygmus） adopting the software of Stata 12 and Rev Man 5. 3.Results Sixteen papers accorded with standard were included. The total sample size was 2247 cases. Only 4 papers recorded concrete random allocation methods. Meta analysis results showed that Houpo Paiqi Mixture was effective on disorders of gastrointestinal motility after operations

such as abdominal non gastrointestinal anastomosis

gynecologic operations

cesarean sections. It could shorten the first flatus time after operation（ WMD =- 11. 82

95% CI:- 14. 80

-

8. 84

P

<

0. 01; WMD =- 18. 19

95% CI:- 27. 58

-

8. 79

P

<

0. 01; WMD =- 10. 95

95%CI:- 16. 22

-

5. 69

P

<

0. 01）

the first defecation time（ WMD =- 8. 58

95% CI:- 15. 95

-

1. 21

P =0. 02; WMD =- 28. 4

95% CI:- 35. 4

-

20. 68

P

<

0. 01; WMD =- 15. 74

95% CI:- 30. 29

-

1. 20

P = 0. 03） and the recovery time of borborygmus（ WMD =- 3. 52

95% CI:- 5. 08

-

1. 96

P

<

0. 01; WMD =- 8. 68

95% CI:- 10. 37

-

6. 99

P

<

0. 01; WMD =- 9. 58

95% CI:- 14. 16

-

5. 01

P

<

0. 01）. No obvious drug adverse reaction. Conclusion Houpo Paiqi Mixture was effective in treating disorders of gastrointestinal motility after operation. There was no obvious drug adverse reaction during short-term application.