Objective To study the relation between Chinese Medical types of syndrome differentiation in Breast Cancer and sensibility of neoadjuvant chemotherapy and prognosis. Methods A total of 161 women with incipient breast cancer who required neoadjuvant chemotherapy were chosen for the study

including 120 cases with liver depression to phlegm stagnation syndrome

38 cases with imbalance of Chong and Ren Channels syndrome

and 3cases with weakened body resistance and serious toxin. All patients received ET scheme of neoadjuvant chemotherapy for 2

6 cycle. Within two weeks after chemotherapy

the patients received surgery. After surgery the pathological curative effect was routinely assessed and positive expression of estrogen receptor（ ER）

progesterone receptor（ PgR）and human epidermal growth factor receptor 2（ HER2） in tumor tissue were detected. The pathological curative effect and duration of disease free survival（ DFS） in patients with different syndrome types were compared. Results Rate of positive ER in the patients with liver depression to phlegm stagnation syndrome was 64. 1%

higher than44. 7% in the patients with imbalance of Chong and Ren Channels syndrome（ P = 0. 035）. There was no statistically significant difference between patients with the two respectively syndrome types in age

clinical stage

histological grade and condition of PgR and HER2（ P

>

0. 05）. Pathologic complete catabatic rate in the patients with liver depression to phlegm stagnation syndrome was 16. 7%

significantly less than 31. 6% in the patients with imbalance of Chong and Ren Channels syndrome（ P = 0. 046）. DFS of the patients with liver depression to phlegm stagnation syndrome was longer than that of the patients with imbalance of Chong and Ren Channels syndrome（ P = 0. 034）

the same in the patients with positive ER（ P

<

0. 05）. Conclusion Pathologic complete catabatic rate about neoadjuvant chemotherapy in patients with breast cancer and liver depression to phlegm stagnation syndrome was low

but the DFS was high. Its molecular mechanism may be associated with ER condition.