Objective To evaluate the effect and safety of Jintong Keli（ 金童颗粒） in treating Tic disorder（ TD）in children with syndrome of deficiency of kidney Yin and liver wind stirring up internally. Methods The trial method of randomized

controlled

double-blind and double simulation was adopted. TD children patients with the syndrome of deficiency of kidney Yin and liver wind stirring up internally

diagnosed by Tianjin University of Traditional Chinese Medicine and other 4 centers from November

2004 to August

2005

were randomized into a trial group and a control group

with 120 cases in each group. The trial group was given Jintong Keli orally and simulated drug of tiapride hydrochloride tablets. The control group was given tiapride hydrochloride tablets orally and simulated drug of Jintong Keli. Both groups were treated for 6 weeks. The scores of Yale Global Tic Severity Scale（ YGTSS）were compared before treatment

and in the 2nd

4th and 6th week after starting treatment. Therapeutic effects for disease or syndrome

as well as safety were evaluated after treatment. Results The total effective rate for disease in the treating group and the control group were 78. 8% and 72. 7%

respectively

and the total effective rate for syndrome were 93. 8% and 97. 3%

respectively

both with no significant difference between the two groups（ P >0. 05）. The scores of YGTSS in both groups in the 2nd

4th and 6th weeks after starting treatment were lower than those in the same group before treatment（ P < 0. 05）. There were no significant differences in scores of YGTSS between the two groups at the same time-point（ P > 0. 05）. Conclusion Jintong Keli is effective and safe in treating TD in children with syndrome of deficiency of kidney Yin and liver wind stirring up internally

with the effect not worse than that of tiapride hydrochloride tablets.