Energy metabolism is one of the causes of depression

and mind lacking of nourishment due to spleen deficiency unable to send nutrients upward is the Chinese medicine pathogenesis of depression induced by energy metabolism disorder. Mitochondria may be the ultrastructural basis of depression induced by energy metabolism disorder.In stress state

the endoplasmic reticulum and mitochondria dysfunction may lead to a decrease in adenosine triphosphate（ ATP） and neuronal apoptosis. Autophagy is an important regulation and control mechanism of depression.