Objective To explore the possible mechanism of Yishen Chuanning Decoction（ 益肾喘宁汤） in treating bronchial asthma of kidney-qi deficiency syndrome using nuclear magnetic resonance. Methods Randomly divided 42 Wistar rats into normal control group

model group and the Chinese medicine group

with 14 rats in each.Except for the normal control group

rats were treated with exhausting swimming and great fright impairing the kidney to establish bronchial asthma of kidney-qi deficiency syndrome model. The Chinese medicine group was given Yishen Chuanning Decoction 2. 0 g /（ kg·d） for gavage from the 15 th day of experiment. The normal control group and the model group were given equal dose saline for gavage. Collected blood from aorta abdominalis and separated serum of rats in each group after 15 days of continuous gavage. Conducted H-nuclear magnetic resonance examination. Finally selected and authenticated different metabolite of rats in different groups. Results Totally authenticated 20 kinds of serum metabolites whose difference had statistic significance. Compared to those in the normal control group

isoleucine and glutamine levels remarkably increased while that of the lactic acid remarkably decreased in the model group.Compared with the model group

lactic acid level in the Chinese medicine group remarkably increased

while the lipid（ R-CH

3

）

lipid（ R-CH

2

）

lipid（ CH

2

CH

2

CO）

lipid（ CH

2

C = C）

lipid（ C = CCH

2

C = C） and unsaturated fatty acid levels decreased（ P

<

0. 05）. Conclusion The possible functional mechanism of Yishen Chuanning Decoction（ 益肾喘宁汤） in treating bronchial asthma of kidney-qi deficiency syndrome is to promote body lipid metabolism and improve energy metabolism deficiency of the body.