Treatment based on syndrome differentiation is the key step in planning treating principles

describing formulas and treating diseases. As the development of Chinese clinical practice

physicians in each dynasty inherits the former experiences and innovates

and form the plentiful Chinese medicine syndrome differentiation system. This paper overviews the historical evolution and modern development of Chinese medicine syndrome differentiation system

and systematically reviews the establishment and development process of Chinese medicine syndrome differentiation system. By comparing the features and advantages of each syndrome differentiation system

the authors aim at offering some reference for the thinking of clinical syndrome differentiation and treatment.