Objective To compare the differences in regulating immune related pathways in influenza A（ H1N1） between Huoxiang（ Agastache rugosus

藿香） and Cangzhu（ Rhizoma Atractylodis

苍术） which are aromatics with different channel tropism. Methods The chemical composition and target protein of aromatics Huoxiang with the lung tropism and Cangzhu without the lung tropism were searched in Taiwan Chinese Medicine Database

Pub Chem

and Traditional Chinese Medicine Integrated Database（ TCMID）. Related genes of influenza A（ H1N1）were searched in Gene database. The correlation of molecular network and biological pathway of Huoxiang target protein

Cangzhu target protein and related genes of influenza A（ H1N1） were analyzed with bioinformatics software.Differences in the effect of two herbs on influenza A（ H1N1） immune related pathways were compared. Results There were 42 Huoxiang target proteins

24 Cangzhu target proteins

and 32 related genes of influenza A（ H1N1）.There were a lot of correlations between influenza A（ H1N1） molecular network and Huoxiang molecular network

but relatively fewer correlations between influenza A（ H1N1） molecular network and Cangzhu molecular network were.Compared with Cangzhu

Huoxiang could work on more immune inflammatory diseases related to influenza A（ H1N1）. Both Huoxiang and influenza A（ H1N1） acted on the same 10 immune biological pathways. Both Cangzhu and influenza A（ H1N1） acted on the same 4 immune biological pathways. Conclusion Aromatics Huoxiang

which was with the lung tropism

might have more advantages in influenza A（ H1N1） immunoregulation than aromatics Cangzhu which was not with the lung tropism.