Objective To analyze the medication rules by national traditional Chinese medicine master Prof. LIU Shangyi in the treatment of menstrual disorders adopting data mining technology. Methods Records of 147 patients with menstrual disorders who visited Prof. LIU Shangyi in Guo Yi Tang Clinic from January to November

2014 were collected. Patients’ clinical data and prescription（ herbs） information were extracted. Herbs used frequencies were counted with Auxiliary System of Traditional Chinese Medicine Inheritance（ V2. 5）. Herb combinations and prescription rules were analyzed with association rules

entropy clustering and complex system entropy clustering. Results One hundred and forty-seven patients were given 137 herbs totally. Top 5 frequent used herbs were

in order

Chuanxiong（ Rhizoma Ligustici Chuanxiong

川芎）（ 113）

Danggui（ Radix Angelicae Sinensis

当归）（ 104）

Yujin（ Radix Curcumae

郁金）（ 81）

Ezhu（ Rhizoma Curcumae

莪术）（ 76） and Foshou（ Citrus Chirocarpus

佛手）（ 73）

and herbs combinations were

in order

Danggui-Chuanxiong（ 96）

Foshou-Yujin（ 73）

Chuanxiong-Yujin（ 70）

Chuanxiong-Ezhu（ 67） and Danggui-Yujin（ 65）. Top 5 correlations between herbs based on modified mutual information method were

in order

Ezhu-Fabanxia（ Rhizoma Pinelliae Preparatum

法半夏）（ 0. 0359）

YujinShengdihuang（ Radix Rehamnniae

生地黄）（ 0. 0352）

Yujin-Zelan（ Herba Lycopi

泽兰）（ 0. 0332）

ChuanxiongZelan（ 0. 0326） and Chuanxiong-Qiancao（ Radix Rubiae

茜草）（ 0. 0326）. There were 18 herb core combinations in total based on complex system entropy clustering

mainly including Ezhu

Chuanxiong

Liujinu（ Artemisia anomala

刘寄奴）

Huangqin（ Radix Scutellariae

黄芩）

Fabanxia

Binlang（ Semen Arecae

槟榔）

Tusizi（ Semen Cuscutae

菟丝子）

Zaojiaoci（ Spina Gleditsiae

皂角刺）

Baijiezi（ Semen Brassicae

白芥子）

Danggui

Yimucao（ Herba Leonuri

益母草）

Yujin

Huangbai（ Cortex Phellodendri

黄柏） and Foshou. Conclusion Prof. LIU Shangyi is good at using herbs of Yang and emphasizes regulating the liver when treating menstrual disorders. In addition to promoting blood circulation

replenishing blood

as well as nourishing liver and kidney

methods of regulating Qiflowing

eliminating dampness

dissipating phlegm

etc. are combined usually.