Dropouts

withdrawals or loss to follow-ups during the clinical trial are nearly inevitable

causing outcome data of some of the participants were unavailable

and lead to missing data during the statistical analyses. If missing data was inappropriately handled

it may therefore be prone to biased estimates and affect the reliability of results. Missing data should therefore be paid attention to at the design

conduct

analysis and report stages of a trial.By putting forward some recommendations on method of handling missing data

reporting specification of dropouts’ information

trial design

and improving participants’ adherence

this article was to provide a valuable reference to improve the robustness of data and conclusion of trial.