Objective To observe clinical efficacy and safety of Shujin Tongluo Granule（舒筋通络颗粒） in the treatment of cervical spondylosis of nerve root and vertebral artery type with liver and kidney deficiency and Qi deficiency and blood stasis syndrome. Methods There were 2170 patients divided into cervical spondylosis of nerve root type（ 1199 cases） and cervical spondylosis of vertebral artery type（ 971 cases） depending on disease type. All patients took Shujin Tongluo Granule orally

12 g each time

three times a day for 4 weeks. Before treatment

as well as 2weeks and 4 weeks after treatment

scores of Chinese medical syndrome

clinical signs and symptoms of patients were evaluated and adverse events occurred during treatment were recorded by researchers. Results A total of 1155 patients in the cervical spondylosis of nerve root type group and 956 patients in the cervical spondylosis of vertebral artery type group completed the study. Two weeks and 4 weeks after treatment

the scores of Chinese medical syndrome

clinical signs and symptoms of the patients with cervical spondylosis of nerve root and vertebral artery type were significantly lower than those before treatment（ P

<

0. 05）

especially in 4 weeks after treatment（ P

<

0. 05）.The effective rates of clinical symptoms and signs were 40. 64%

65. 08%

and the effective rates of Chinese medical syndrome indexes were 34. 08%

57. 48% two weeks after treatment

but 71. 03%

83. 88% and 63. 98%

8

2. 17% respectively 4 weeks after treatment. There were adverse events occurring in 75 patients during treatment

including 63 cases with different degree of gastrointestinal discomfort which were related to drug and can alleviate after drug withdrawal. Conclusion With good safety

Shujin Tongluo Granule may effectively improve typical clinical manifestations of cervical spondylosis of nerve root and vertebral artery type with liver and kidney deficiency and Qi deficiency and blood stasis.