Objective To observe the effect of Xiaoxinbi Fang（ 消心痹方） combined with western medicine on Chinese medicine symptoms and left ventricular function of hypertrophic cardiomyopathy（ HCM）. Methods Randomly divided 67 cases of patients with HCM proved by Color Doppler Echocardiography into a control group with 33 cases and a treatment group with 34 cases. The control group was given Betaloc sustained release tablets（47. 5 mg orally

once per day） and adjusted the dose according to blood pressure and heart rates. The treatment group was given Xiaoxinbi Fang in addition to the treatment of the control group

one dose per day. The treatment courses were both for 90 days. Observed curative effects of Chinese medicine symptoms

including chest distress

chest pain

heart palpitations

fatigue

shortness of breath and dizziness. Using echocardiography to examine the variation of interventricular septal thickness（ IVS）

left ventricular posterior wall thickness（ IVPW） and their ratio（ IVS / IVPW） before and after treatment. Examined NT-pro BNP content in plasma and compared the change of NYHA ranking level of both groups before and after treatment. Results The total effective rates of chest pain

heart palpitations

fatigue

shortness of breath of the treatment group after treatment was remarkably superior to those of the control group（ P <0. 05）. The levels of NT-pro BNP in the two groups after treatment were both remarkably lower than those before treatment（ P < 0. 01）; IVS

IVPW and IVS / LVPW in the treatment group after treatment remarkably decreased compared with those before treatment（ P < 0. 05）; NT-pro BNP levels of the treatment group after treatment as well as IVS

IVPW and IVS / LVPW were all lower than those of the control group（ P < 0. 05）. NYHA cardiac functional grading in the two groups after treatment both remarkably decreased

with the treatment group superior to the control group（ P < 0. 05）. Conclusion Xiaoxinbi Fang combined with western medicine can improve clinical symptoms of patients with HCM and improve left ventricular function.