Objective To observe clinical efficacy treated by "Sanjiao acupuncture"in patients with cancerrelated fatigue. Methods Eighty patients with malignant tumor were divided into a control group and a treatment group

with 40 cases in each. Both groups were treated with basic treatment of Chinese and Western medicine; The treatment group was added additionally with "Sanjiao acupuncture"treatment at points Danzhong（ RN 17）

Zhongwan（ RN 12）

Qihai（ RN 6）

Xuehai（ SP 10

bilateral）

Zusanli（ ST 36

bilateral）

and Waiguan（ SJ 5

bilateral）

once daily. Both groups were treated for 2 weeks. Changes of Chinese medicine syndromes score

fatigue

anxiety and depression

quality of life in the two groups were compared by using Symptomatic Grading and Quantifying Scale

Multidimensional Fatigue Inventory（ MFI）

Hospital Anxiety Depression Scale（ HADS）

and Function Assessment of Cancer Therapy-Fatigue（ FACT-F）

and the curative effects on Chinese medicine syndrome were evaluated.Results In the treatment group

the total effective rate was 75%

which was significantly better than 45% in the control group（ P < 0. 01）. After treatment

the Chinese medicine syndromes score in the both groups were lower than that before treatment（ P < 0. 05 or P < 0. 01）

and the Chinese medicine syndromes score in the treatment group was lower than that in the control group（ P < 0. 01）. The scores of fatigue

anxiety and depression after treatment were significantly lower than before treatment in the treatment group

and the quality of life scores in the treatment group were higher than those before treatment（ P < 0. 05 or P < 0. 01）

while the scores of fatigue

anxiety and depression

quality of life in the treatment group were better than those in the control group（ P < 0. 01）. Conclusion "Sanjiao acupuncture"can effectively improve fatigue of cancer patients and the related anxiety and depression

and also improve the quality of life.