Objective To observe clinical curative effects of Yangyin Tongluo Formula（ 养阴通络方） combined with Hydroxychloroquine Sulfate Tablets in treating primary Sjogren’s syndrome. Methods Sixty patients with primary Sjogren’s syndrome were randomly divided into a treatment group and a control group

with 30 cases in each.Two groups were both given Hydroxychloroquine Sulfate Tablets orally

0. 2 g each time

twice per day. The treatment group was also given Yangyin Tongluo Formula

one dose per day. The control group was also given Total Glucosides of Paeony Capsules（ 白芍总苷胶囊）

0. 6 g each time

twice per day. Two groups were both treated for 3 months. Eye drying degree was evaluated using wetting length of filter paper

and mouth dying degree was evaluated using the time of melting by mouth holding before and after treatment. And levels of Erythrocyte Sedimentation Rate（ ESR）

gamma globulin and immunoglobulin G（ Ig G）

immunoglobulin A（ Ig A）

immunoglobulin M（ Ig M） were tested. After treatment

clinical curative effects were also evaluated. Results The total clinical effective rate was 83. 33% in the treatment group while 56. 7% in the control group. The treatment group was remarkably superior to the control group（ P < 0. 01）. The time of melting by mouth holding

and levels of ESR

gamma globulin

and Ig G

Ig A and Ig M in both groups after treatment all remarkably improved compared with that before the treatment（ P < 0. 05 or P < 0. 01）.And the improvement of all indexes in the treatment group was superior to that in the control group except for wetting length of filter paper（ P < 0. 05）. Conclusion Yangyin Tongluo Formula（ 养阴通络方） combined with Hydroxychloroquine Sulfate Tablets shows obvious curative effect in treating primary Sjogren’ s syndrome. It could improve symptoms like mouth drying and eyes drying

which may be related to decreasing ESR and regulating immune.