Objective To make initial location of familial hallux valgus relating genes and to provide theoretical basis for Chinese medicine treatment of hallux valgus. Methods By epidemiological investigation

the diagnostic criteria of the disease genetic factor group were confirmed. A family sample of hallux valgus was collected with the biggest sample size known so far. Whole-genome scan and linkage analysis was made on the sample. The characteristics of genes contained in these regions were analyzed. Results Six relating chromosomal regions were found; most were genes related to bones and muscles development. The expressions of these genes could be influenced by Chinese herbal compound of invigorating kidney and semen

calcium supplement and strengthening bones. Conclusion The research result might provide the most intuitive basis for further study on hallux valgus molecular genetic mechanism. It might also provide evidence of gene molecular level for Chinese medicine treatment of hallux valgus.