Objective To observe clinical curative effect of Yiqi Huoxue Decoction combined with dual antiplatelet western medicine in treating coronary heart disease with Qi deficiency and blood stasis syndrome. Methods Historical control was conducted as study design. The treatment group included 50 outpatients with coronary heart disease with Qi deficiency and blood stasis syndrome treated from November 2013 to December 2015. The control group consisted of 50 outpatients with coronary heart disease with Qi deficiency and blood stasis syndrome accepting dual anti-platelet western medicine conventional therapy（ Aspirin Enteric-coated Tablets 100 mg per day orally + Clopidogrel Hydrogen Sulphate Tablets 75 mg per day orally） from December 2010 to January 2012. The treatment group used Chinese medicine of tonifying Qi and activating blood additionally on the basis of conventional therapy of dual anti-platelet western medicine

one dose per day. Maximum platelet aggregation rate

angina scores

Qi deficiency and blood stasis syndrome scores and blood stasis syndrome scores of patients in the two groups before treatment and four weeks and three months after treatment

and number of gastrointestinal adverse reaction cases and score variation before treatment

in the follow-up visit 3 months and 6 months after treatment were observed. Results Compared with that before treatment

maximum platelet aggregation rate

angina scores

Qi deficiency and blood stasis syndrome scores and blood stasis syndrome scores of patients in the treatment group decreased four weeks and three months after treatment（ P < 0. 05 or P < 0. 01）; compared with four weeks after treatment

angina scores

Qi deficiency and blood stasis syndrome scores and blood stasis syndrome scores of patients in the treatment group decreased more remarkably three months after treatment（ P < 0. 05）; in the 6 months follow-up visit after treatment

gastrointestinal adverse reaction integral in the treatment group increased（ P < 0. 01）. Compared with the control group at the same time point

maximum platelet aggregation rate

angina scores

Qi deficiency and blood stasis syndrome scores and blood stasis syndrome scores of patients decreased four weeks and three months after treatment（ P < 0. 05 or P < 0. 01）

and gastrointestinal adverse reaction integral decreased in the 3 and 6 months follow-up visit after treatment in the treatment group（ P < 0. 05）. Conclusion Yiqi Huoxue Decoction combined with dual anti-platelet western medicine could further decrease platelet aggregation rate

improve clinical symptom and decrease gastrointestinal adverse reactions induced by dual anti-platelet western medicine.