Objective To examine the clinical effect of Shenfu Injection assisting routine western drug to treat coronary heart disease with chronic heart failure. Methods Totally 102 cases of coronary heart disease with chronic heart failure with syndrome of Yang deficiency of heart and kidney were randomized into a treatment group（ 51 cases）and a control group（ 51 cases）. The control group was given western medicine routine therapy. The treatment group was given Shenfu Injection 40 ml / d intravenous drip to assist western medicine routine therapy. The Minnesota Living with Heart Failure questionnaire（ MLHFQ） was applied to evaluate quality of life before and 2 weeks after treatment.Chinese medicine syndrome score was rated before

and 1 week and 2 weeks after treatment. Survival condition analysis was made by telephone or during outpatient follow-up. Results After 2 weeks of treatment

as for Chinese medicine syndrome effect

there were 19 cases markedly improved

22 improved

6 invalid

and 4 getting worse in the treatment group

with the total effective rate of 80. 39%. In the control group

there were 13 cases markedly improved

21 improved

10 invalid

and 7 getting worse

with the total effective rate of 66. 67%. The treatment group was superior to the control group（ P < 0. 05）. The total score of MLHFQ in both groups decreased 2 weeks after treatment（ P < 0. 05）. The total score of Chinese medicine syndrome in both groups decreased one and 2 weeks after treatment（ P < 0. 05）. The total score of Chinese medicine syndrome in the treatment group 2 weeks after treatment was lower than that in the control group at the same time point（ P < 0. 05）. The survival rate of the treatment group was 96. 1%

higher than 82. 4% in the control group（ P < 0. 05）. Conclusion Shenfu Injection assisting western drug routine therapy might enhance the clinical effect

extend survival time

relieve clinical symptoms

and improve quality of life in the treatment of coronary heart disease with chronic heart failure.