Objective To explore possible mechanism of Qinghua Granule（ 清化颗粒） treating type 2 diabetic mellitus. Methods Randomly divided 24 db / db mice with diabetes into the model control group and the Qinghua Granule low

middle and high dose group

with 6 in each group. Set another 6 db / m mice as the blank control group.The Qinghua Granule low

middle and high dose groups were respectively given Qinghua Granule 3. 77

7. 54 and15. 08 g /（ kg·d） for gavage. The model control group was given normal saline 10 ml /（ kg·d） for gavage. The blank control group had no other management. All groups were continuously observed for four weeks. After the management

examined levels of fasting blood-glucose

serum hemoglobin A1c（ Hb A1c）

serum glucagon-like peptide-1（ GLP-1） concentration and the expression of glucose transporter2（ GLUT2） mRNA and protein in ileum tissue.Results Compared with the blank control group

fasting blood-glucose and Hb A1 levels of mice in the model control group remarkably increased while serum GLP-1 concentration

the expression of GLUT2 mRNA and protein in ileum tissue all remarkably decreased（ P < 0. 01）. Compared with that in the model control group

in the Qinghua Granule low

middle and high dose groups

levels of fasting blood-glucose and Hb A1 c all decreased

while serum GLP-1 concentration

the expression of GLUT2 mRNA and protein in ileum tissue increased. The Qinghua Granule high dose group had the best effect（ P < 0. 05 or P < 0. 01）. Conclusion Qinghua Granule could decrease levels of fasting blood-glucose and Hb A1 c of db / db mice with diabetes and promote secretion of GLP-1. Its function may be related to increase of the expression of GLUT2 in ileum tissue.