Objective To evaluate clinical curative effect and safety of Liugan Shuangjie Decoction（ 流感双解方）in treating mild influenza virus pneumonia. Methods Fifty-two 52 patients with influenza virus pneumonia were randomly divided into a Chinese medicine group and a control group

with 26 cases in each. Patients in two groups received basic treatment. Additionally

patients in the Chinese medicine group with disease involving both weifen and qifen syndrome took Liugan Shuangjie Decoction No. 1

while those with qifen heat excess syndrome took Liugan Shuangjie Decoction No. 2

one dose per day

for 10 days in total. The control group orally took Oseltamivir phosphate capsule 75 mg per time

twice per day

and drugs were stopped after 5-day treatment. Then the basic treatment was continually given for 10 days in total. After treatment

clinical curative effect

temperature recovery time

average onset time

negative conversion ratio of influenza virus antigen

and pneumonia absorption state on x-ray chest film were evaluated. Before and after treatment

Chinese syndrome grading was conducted and safety indexes were observed. Results The total clinical curative effect was 92. 3% in the Chinese medical group

while 88. 5% in the control group. There was no statistical significance in the difference between two groups（ P > 0. 05）. In the middle of treatment

after treatment and in follow-up visit

Chinese syndrome scores of patients in two group remarkably decreased compared with that before treatment（ P < 0. 05）. There was no statistical significant difference in average onset time

temperature recovery time

evaluation of pneumonia absorption on x-ray chest film and negative conversion ratio of influenza virus antigen between the two groups（ P > 0. 05）. Severity of adverse events of patients in two groups was all light. Causal relationship between adverse events and drugs was all judged to be doubtful or impossible.Conclusion Liugan Shuangjie Decoction could improve clinical symptoms of patients with mild influenza virus pneumonia

and effectively promote pneumonia absorption and negative conversion of influenza virus antigen. Its curative effect was equal to Oseltamivir phosphate capsule and had good safety.