Effects of Guanxin Danshen Dripping Pill(冠心丹参滴丸) on Blood Stasis Syndrome Scores and Levels of Serum associated Adhesion Factors in Chronic Stable Angina Patients with Blood Stasis Syndrome
QU Hua, GUO Ming, CHAI Hua, et al. Effects of Guanxin Danshen Dripping Pill(冠心丹参滴丸) on Blood Stasis Syndrome Scores and Levels of Serum associated Adhesion Factors in Chronic Stable Angina Patients with Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2017, 58(5): 394-397.
QU Hua, GUO Ming, CHAI Hua, et al. Effects of Guanxin Danshen Dripping Pill(冠心丹参滴丸) on Blood Stasis Syndrome Scores and Levels of Serum associated Adhesion Factors in Chronic Stable Angina Patients with Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2017, 58(5): 394-397.DOI: 10.13288/j.11-2166/r.2017.05.010.
Objective To observe clinical curative effect of Guanxin Danshen Dripping Pill( 冠心丹参滴丸) on chronic stable angina patients with blood stasis syndrome. Methods Using randomized
double-blind
placebo controlled method
divided 240 cases of chronic stable angina patients with blood stasis syndrome into a treatment group and a control group
with 120 cases in each group. In addition to the conventional western medicine treatment
the treatment group was orally given Guanxin Danshen Dripping Pill
the control group was given placebo
0. 4 g each time
3 times per day
for 1 month. Before and after treatment
observed Chinese medicine main symptom scores
blood stasis syndrome scores
and levels of serum soluble intercellular adhesion molecule-1( s ICAM-1) and soluble vascular cell adhesion molecule-1( s VCAM-1)
and also observed the adverse reaction. Results Totally 108 cases were included in the treatment group
104 cases included in the control group. After treatment
Chinese medicine main symptom scores
blood stasis syndrome scores
the levels of s ICAM-1and s VCAM-1 in both groups were significantly lower than those before treatment( P < 0. 05). After treatment
the reduction of the blood stasis syndrome scores
s ICAM-1 and s VCAM-1 levels in the treatment group were more significant than those in the control group( P < 0. 05). There were no serious adverse reactions during the treatment in both groups. Conclusion In chronic stable angina patients with blood stasis symptom
Guanxin Danshen Dripping Pill could significantly reduce the blood stasis symptom scores as well as the levels of s ICAM-1 and s VCAM-1.