Objective To explore the effect of Qufeng Zhidong Decoction（ 祛风止动方） on expression level of regulatory T cells（ Treg） in peripheral blood of child patients with tic disorder. Methods Thirty children patients with tic disorder were collected as the treatment group. Another 20 healthy children were selected as the control group. The treatment group was given Qufeng Zhidong Decoction granules 1 dose per day for 3 months. The expression of Treg in peripheral blood of subjects was tested before and after treatment in the treatment group

and at the time when entered group in the control group. Results Before treatment

the expression level of Treg in peripheral blood of children in the treatment group was remarkably lower than that in the control group. At their preschool period（ 3

6

years old） and school age（ 7

16 years old）

the expression level of Treg in peripheral blood in the treatment group also decreased compared with the control group（ P

<

0. 01）. After treatment The expression level of Treg in peripheral blood of child patients in the treatment group at their preschool period and school age all showed rising trend compared with that before treatment

but there was no statistical significance in differences（ P

>

0. 05）. Conclusion Abnormal expression of Treg is related to the attack of tic disorder. Qufeng Zhidong Decoction has up-regulation effect on Treg expression of child patients with tic disorder.