Objective To explore possible mechanism of Huwei San（ 护胃散） in treating gastric mucosal injury in rush entry into plateau. Methods Randomly divided 350 Wistar rats into Beijing group

Xining group

Madoi blank group

Madoi positive control group and Huwei San high

middle and low dose groups

with 50 rats in each group. Except for Beijing group

the other 300 rats were delivered to Xining city by air. The Madoi blank group

Madoi positive control group and Huwei San high

middle and low dose groups were successively delivered to Madoi County by bus on that day. Beijing group

Xining group and the Madoi blank group were perfused with 2ml saline.Madoi positive control group was given Jinghua Weikang Capsule（ 荆花胃康胶丸） 2. 4 g/（ kg·d）. Huwei San low

middle and high dose group were respectively given Huwei San of 2. 6 g/（ kg·d）

5. 2 g/（ kg·d） and 10. 4 g/（ kg·d）

for 7 days totally. Ten rats in each group were sacrificed on the 1st

2nd

3rd

5th and 7th day of the experiment. Took gastric mucosal tissue and conducted pathological observation. At the same time

examined the expression of mRNA of vascular endothelial growth factor（ VEGF） and basic fibroblast growth factor（ bFGF） in gastric mucosa.Results There were scattered hemorrhagic spots

erosion or superficial ulcer in surface of gastric mucosa and defect change in local mucosa of rats in the Madoi blank group; congestion and inflammation exudation in submucosal vessels in the Huwei San high dose group improved much compared with the Madoi blank group. Compared with that in the Madoi blank group at the same time

there were different levels of expression increase of VEGF

and bFGF mRNA in the Huwei San high and middle dose groups on the 3rd and 5th day. And on the 2nd and 3rd day

the expression increase of VEGF mRNA in the Huwei San high dose group was superior to the Madoi positive control group（ P < 0. 05 or P < 0. 01）. Conclusion Huwei San could increase the expression of VEGF and bFGF mRNA in gastric mucosa of rats with rush entry into plateau. Thus it could improve repair of gastric mucosal injury in rush entry into plateau.