Objective To evaluate the intervening effect of Aikeqing Compounds on acquired immune deficiency syndrome（AIDS） model monkeys. Methods Eight rhesus monkeys infected with Simian immunodeficiency virus（SIV） at the same time were randomly divided into the Chinese medicine group and antiviral agent group

with 4 monkeys in each group. The Chinese medicine group was given 1 g/（kg·d） of Aikeqing Compounds extract for gavage. The antiviral agent group was given 30 mg/（kg·d） of tenofovir for subcutaneous injection in back. Both groups were treated once daily for 8 weeks. Samples of peripheral blood and superficial lymph node were collected before and after medication

and tissue samples of s stomach

thymus and spleen were taken when experiment ended. Levels of CD3

CD4

CD8

chemokine receptor CCR5

and viral loads in different samples were examined. And then pathological analysis was conducted. Results Level of CD4 in peripheral blood

stomach and mesenteric lymph nodes

the expression of chemotactic factor CCR5 in rectum in the Chinese medicine group were higher than those in the antiviral agent group（P <0. 05）

and pathologic structure of thymus

spleen and superficial lymph node tissue were conserved more complete in the Chinese medicine group. Viral loads in mesenteric lymph nodes in the antiviral agent group were lower than that in the Chinese medicine group（P < 0. 05）. Conclusion Aikeqing Compounds seems to have certain immunomodulatory effect on AIDS model monkeys.