Objective To explore the effect and possible mechanism of Kuntai Capsule（ 坤泰胶囊） in treating uterus myoma. Methods Forty-three SD rats were randomized into modeling group（ n = 36） and blank group（ n =7）. Uterus myoma rat models were built in the modeling group by estrogen and progesterone loading method. Thirtysix successfully modeled rats were randomized into model group

estradiol group and Kuntai group

with 12 in each group. The Kuntai group was given Kuntai Capsule 0. 5 g/（ kg·d） by gavage. The estradiol group was given estradiol valerate tablet 50 μg/（ kg· d） by gavage. The blank group and the model group were given normal saline 10 ml/（ kg·d） by gavage once every day

for 30 days. Rats’ uterine morphology and pathologic histology changes were examined. The estradiol（ E

2

） and progesterone（ P） levels were detected. Semi quantitative analysis score was made on the protein expressions of uterine tissue estrogen receptor（ ER）

progesterone receptor（ PR）

basic fibroblast growth factor（ b FGF）

vascular endothelial growth factor（ VEGF）

transfer growth factorβ3（ TGF-β3）

X protein associated to gene2 of B lymphocyte tumor（ Bax）

B lymphocyte tumor-gene2（ Bcl-2） and proliferating cell nuclear antigen（ PCNA）. Results Compared with the normal group

uterine weight

maximum diameter of cervix

maximum diameter of uterine body

uterine coefficient

serum levels of E

2

and P

uterine tissue protein expressions of ER

PR

VEGF

b FGF

TGF-β3

Bcl-2 and PCNA in the model group increased

while Bax protein expression decreased（ P

<

0. 05 or P

<

0. 01）. Compared with the model group

maximum diameter of cervix

maximum diameter of uterine body

serum levels of E2 and P

uterine tissue protein expressions of ER

PR

VEGF

b FGF and TGF-β3 in the KUntai group and the estradiol group decreased

while Bax protein expression increased（ P

<

0. 05 or P

<

0. 01）.Moreover

maximum diameter of cervix

maximum diameter of uterine body

as well as serum levels of E2 and P in the Kuntai group were lower than those in the estradiol group; Bax protein expression was higher than it in the estradiol group（ P

<

0. 05）. Conclusion Kuntai Capsule might inhibit the growth of uterus myoma. Regulating estrogen

progesterone and the receptors

inhibiting related growth factors

promoting apoptosis and inhibiting cell proliferation might be one of the mechanisms.