Objective To summarize the Chinese medicine syndrome and prescription laws of Ⅳ-stage colorectal cancer patients as well as their treatment outcome intervented with Chinese medicine through statistical analysis of the literature. Methods The authors searched the articles from Jan. 1996 to Dec. 2016 in CBM

CNKI

VIP and Wanfang Database

which involves clinical trials about Chinese medicine syndromes of colorectal cancer. Frequency of the Chinese medicine syndromes

the Chinese medicine herbs

the treatment outcomes including Karnofsky score

median survival time

objective response rate and disease control rate were calculated. Results Totally 58 articles were included with 4291 patients

in which 2438 patients were treated with Chinese medicine and 1586 patients’ Chinese medicine syndromes were recorded. The first 5 common Chinese medicine syndromes were spleen-kidney Yang deficiency（ 33. 5%）

Qi and blood deficiency（ 17. 4%）

internal obstruction of stasis-toxin（ 17. 3%）

spleen deficiency with prevalence of dampness（ 16. 0%） and internal accumulation of damp-heat（ 13. 8%）. There were 138 Chinese medicine herbs in these articles

in which the top five frequently-used ones were Baizhu[Atractylodes macrocephala Koidz. ]（ 50）

Fuling [Poria cocos（ Schw.） Wolf]（ 46）

Huangqi [Astragalus memeranaceus（ Fisch.） Bge. var. mongholicus（ Bge.） Hsiao]（ 38）

Dangshen [Codonopsis pilosula（ Franch.） Nannf. ]（ 35） and Yiyiren [Coix lacryma-jobi L. var. ma-yuen（ Roman.） Stapf]（ 32）. Karnofsky score was reported in28 articles

of which 25（ 89. 3%） reported significant statistical differences; median survival time was reported in 9articles

of which 5（ 55. 6%） reported significant statistical differences; 22 articles reported objective response rate

of which 9（ 40. 9%） reported significant statistical differences; 15 articles reported disease control rate

of which 8（ 53. 3%） reported significant statistical differences（ P < 0. 05）. Conclusion Deficiency in origin and excess in superficiality

deficiency-excess complex and the tendency towards multi-zang organs deficiency seem to be the characteristics of Chinese medicine syndromes of Ⅳ-stage colorectal cancer. The Chinese herbs that can strengthen the body resistance to eliminate pathogenic factors may have some advantages in prolonging median survival rate

improving objective response rate and disease control rate.