This article discusses the Chinese medicine etiology and pathogenesis of organ fibrosis based on the theory of"collateral deficiency and pathogen stasis"of chronic complex disease. It suggests that"Zang-organ collateral deficiency and collateral obstructed by phlegm

stasis and heat toxin"is the common pathogenesis of organ fibrosis from the view of collateral disease. Under the guidance of the core theory of "homeostatic control"in collateral disease and combined with the clinical characteristics of organ fibrosis

this article suggests the therapeutic method in Chinese medicine should be "always supplementing deficiency

treating along with different stages as key

and regulating to achieve harmony"

which providing clinical therapeutic thoughts for organ fibrosis in Chinese medicine.