Objective To evaluate the clinical effect of Liumo Decoction （六磨汤） high retention enema combined with biofeedback on mixed functional constipation.Methods Ninety patients with mixed functional constipation were randomized into treatment group and control group

45 cases in each group.The treatment group was given Liumo Decoction high retention enema combined with biofeedback.The control group was given normal saline high retention enema combined with biofeedback.Both groups were treated once every other day

enema before sleep.Biofeedback therapy was given 1h each time

once every other day

alternate with enema.Both therapies were given 15 times.The course was 30 days.The scores of incomplete evacuation

anus obstructive sense

difficult defecation

stool property

defecation times

defecation time and abdominal distension in both groups were recorded before and after treatment.The therapeutic effect was evaluated after treatment.After the treatment was finished

follow-up was made for 3 months.The recurrence of the clinical symptoms was examined.Results The total effective rate of clinical effect in the treatment group was 75.56%

which was superior to 55.56% in the control group （P < 0.05）.The scores of incomplete evacuation

anus obstructive sense

difficult defecation

stool property

defecation times

defecation time and abdominal distension in the treatment group decreased after treatment.In the control group

the scores of incomplete evacuation and defecation times decreased （P < 0.05）.Moreover

the improvement of the clinical symptoms in the treatment group was superior to that in the control group （P < 0.05）.After 3 months of follow-up

no recurrence of the clinical symptoms was found.Conclusion Liumo Decoction high enema combined with biofeedback treating mixed functional constipation seemed effective

which might improve patients’ clinical symptoms

such as difficult defecation.