Objective To explore the modeling method of rat model of nonalcoholic fatty liver disease（ NAFLD）with intermingled phlegm and blood stasis syndrome. Methods Twenty Sprague Dawley rats were randomized into a control group

a model group

a classical prescription group

and a proved prescription group

n = 5 in each group.Rats in all groups except those in the control group were exposed to the damp environment

multiple factors compound stimulation

external chronic mild irritation

and high fat diet for 10 weeks to establish the models of NAFLD with intermingled phlegm and blood stasis syndrome. After 8 weeks of modeling

the classical prescription group and the proved prescription group were given 1 ml/100 g of corresponding herbal medicine by gavage. The control group and the model group were given equivalent normal saline by gavage

once every day

for 2 weeks. At the 1 st and 10 th week of modeling

tongue manifestation scores（ including tongue color and sublingual vessel） in each group were recorded. At the 10 th week of modeling

liver hematoxylin and eosin（ HE） stain was taken to examine the level of hepatic steatosis. Blood fat and liver enzymology indexes as well as hemorheology indexes including plasma viscosity and whole blood viscosity were detected. Results Compared with those in the control group

rats’ tongue manifestation scores

liver enzymology indexes

blood fat and hemorheology indexes increased in the model group（ P < 0. 05）. The sublingual vessel score in the classical prescription group and the proved prescription group were lower

and the levels of blood fat and liver enzymology indexes decreased compared with that in the model group at the same time（ P <0. 05）. The levels of total cholesterol（ TC）

triglyceride（ TG） and alanine aminotransferase（ ALT） in the proved prescription group were lower than those in the prescription group（ P < 0. 05）. Conclusion The pathology of rat model induced by damp environment

multiple factors compound stimulation

external chronic mild irritation and high fat diet is in accordance with NAFLD

and the model is with Chinese medicine syndrome of intermingled phlegm and blood stasis. After herb-prescription intervention

it is proved by contradiction that model construction is successful.