LI Ji, DAI Yuting, CAI Shiying, et al. Clinical Observation on Bushen Peiyuan Yulin Decoction(补肾培元毓麟汤) in Treating 48 Patients with Secondary Infertility Due to Endometrial Injury[J]. Journal of Traditional Chinese Medicine2017, 58(23): 2020-2024.
LI Ji, DAI Yuting, CAI Shiying, et al. Clinical Observation on Bushen Peiyuan Yulin Decoction(补肾培元毓麟汤) in Treating 48 Patients with Secondary Infertility Due to Endometrial Injury[J]. Journal of Traditional Chinese Medicine2017, 58(23): 2020-2024.DOI: 10.13288/j.11-2166/r.2017.23.010.
Objective To observe the clinical curative effect of self-made Bushen Peiyuan Yulin Decoction( 补肾培元毓麟汤) in treating secondary infertility due to endometrial injury. Methods Divided 97 patients with secondary infertility due to endometrial injury into Chinese medicine group( 51 cases) and control group( 46 cases) according to patients’ will. The Chinese medicine group was given self-made Bushen Peiyuan Yulin Decoction from the fifth day after menstruation
with drug withdrawn during menstruation; the control group took Estradiol Valerate Tablets orally from the fifth day after menstruation
and took Dydrogesterone Tablets in addition after ovulating. Both groups were treated for 6 menstrual cycles. After treatment
the researchers compared the pregnancy rates within 6 months and the20 th week pregnancy rate between the two groups. In the non-pregnancies
the researchers compared the endometrial thickness
the change of menstrual blood volume and the total clinical effective rate. Results The pregnancy rate in the Chinese medicine group within 6 months was 54. 17%
significantly higher than 30. 77% in the control group.And the pass rate of preventing miscarriages to 20 weeks was 92. 31%
significantly higher than 58. 33% in the control group( P < 0. 05). Menstrual blood volume increased and the endometrium thickened in the two groups after treatment than those before treatment
and the difference was statistically significant. The menstrual blood volume improvement degree in the Chinese medicine group was superior to that in the control group( P < 0. 05 or P < 0. 01).The total effective rate of the Chinese medicine group was 93. 75%
better than 74. 31% in the control group( P <0. 05). Conclusion Bushen Peiyuan Yulin Decoction has good effect on improving pregnancy rate of patients with secondary infertility due to endometrial damage
and could improve the menstrual blood volume and endometrial thickness of those patients.