Objective To observe the efficacy of integrative Chinese and western medicine treatment program based on the method of resolving toxin

cooling the blood and draining dampness in the treatment of patients with hepatitis B and acute-on-chronic liver failure at early stage. Methods Sixty-three patients with hepatitis B and acuteon-chronic liver failure at early stage were randomized into integrative medicine group（ 30 cases） and western medicine control group（ 33 cases）. The western medicine control group was given comprehensive treatment of western medicine

in addition

the integrative medicine group was given Jiedu Liangxue Lishi Fang（ toxin resolving

blood cooling and dampness draining decoction

解毒凉血利湿方） for 4 weeks and the patients were followed up for 8 weeks.The changes of hepatic function and coagulation function indexes in both groups before and after treatment were detected. The number of cases progressing to acute-on-chronic liver failure and the cumulative effective cases at different time after treatment were counted

based on which the disease progression rate and the cumulative effective rate were calculated. Results The progression rates of the integrative medicine group were all 6. 67% in the 2 nd

3 rd

4 th week and the 2 nd and 4 th follow-up week

respectively

while that of the western medicine treatment group was24. 24%. The cumulative effective rate of the integrative medicine group was 70. 00% in the 2 nd week while that of the western medicine control group was 45. 45%

with significant difference between groups（ P < 0. 05）. Compared with those before treatment

the levels of alanine aminotransferase and aspartate aminotransferase decreased in both groups in the 2 nd week

while in the integrative medicine group

total bilirubin（ Tbi L） and total bile acid（ TBA） in the 2 nd week

alkaline phosphatase in the 8 th follow-up week and glutamyl-transpeptidase in the 2 nd

4 th and 8 th follow-up weeks decreased; compared with the western medicine control group

the TBi L and TBA in the integrative medicine group decreased in the 2 nd and 3 rd weeks（ P < 0. 05 or P < 0. 05）. Compared with those before treatment

the white cell count and neutrophil count（ NC） decreased in the integrative medicine group in the 4 th week and the4 th and 8 th follow-up weeks after treatment

and the neutrophil lymphocyte ratio（ NLR） decreased in the 2 nd week;compared with those in the western medicine control group

the NC and NLR in the integrative medicine group decreased in the 1 st and 2 nd weeks after treatment

and the lymphocyte count increased in the 4 th and 8 th follow-up weeks（ P < 0. 05 or P < 0. 01）. Conclusion The integrative medicine treatment program combined Chinese and western medicine based on the method of resolving toxin

cooling the blood and draining dampness can reduce the progression rate of hepatitis B patients with acute-on-chronic liver failure in early stage

improve the treatment efficiency and improve the prognosis of patients.