Objective To explore the efficacy and the possible mechanism of the method of inducing sweating to release the exterior（ Yuebi Tang

越婢汤） and the method of supplementing kidney and consolidating essence（ Gujing Fang

固精方） in the treatment of nephrotic syndrome. Methods Forty Wistar rats were randomized into control group

model group

Yuebi Tang group and Gujing Fang group

with 10 rats in each group. Rats in each group except for the control group were given a single intravenous injection of puromycin aminonucleoside 9 mg/100 g to establish the model of glomerular podocyte injury. On the second day after modeling

Yuebi Tang group was orally administered Yuebi Tang（ 2. 1 g/100 g） daily

the Gujing Fang group was orally given Gujing Fang（ 7. 5 g/100 g） daily

while the control group and the model group were given equal volume of distilled water. The treatment period was 2 weeks. The levels of serum creatinine

urea nitrogen

uric acid

albumin

total cholesterol

triglyceride

urinary protein and urinary creatinine

TRPC5 and TRPC6 protein and mRNA expressions in renal tissue of rats in each group were measured

and glomerular pathological changes and podocyte ultrastructure were observed. Results Compared with those in the control group

the levels of urea nitrogen

uric acid

total cholesterol and triglyceride in the model group increased

serum albumin decreased

urinary protein creatinine ratio increased

while the expressions of TRPC5 and TRPC6 protein and mRNA in renal tissue increased（ P < 0. 05）. Compared with those in the model group

the serum creatinine

uric acid

total cholesterol

triglyceride and urinary protein creatinine ration decreased in Yuebi Tang group and Gujing Fang group

albumin increased

and the expressions of TRPC5 and TRPC6 mRNA in the renal tissue decreased（ P < 0. 05）. The serum levels of albumin

uric acid and TRPC5 mRNA in renal tissue in Yuebi Tang group were lower than those in Gujing Fang group

while TRPC6 mRNA was higher（ P < 0. 05）. Conclusion Yuebi Tang and Gujing Fang may regulate the protein expressions of TRPC5 and TRPC6 in renal tissue

reduce the podocyte injury

thus improving the low protein and hyperlipemia in nephrotic syndrome.