The authors put forward that the disease location of Alzheimer’s disease（ AD） is at the brain

which closely related to the kidney. The kidney essence and kidney-qi are the material and functional basis of brain marrow and brain spirit. Essence and Qi in kidney deficiency

deficiency of marrow-reservoir and spiritual mechanism dysfunction are the root cause of AD. Regulating regeneration of central nervous system is the potential therapeutic regimen of AD

while Chinese medicine has advantages in regulating regeneration of central nervous. Kidney-brain related theory is the important Chinese medicine theoretical basis for regulating regeneration of central nervous of AD patients;and tonifying essence and benefiting Qi is important methods for promoting central nervous regeneration

which may provide theoretical base for research of Chinese medicine regulating the regeneration of central nervous of AD.