Systemic sclerosis（ SSc） can be attributed to skin Bi（ 痹） syndrome in Chinese medicine

but it is often involving the lungs

and evolves into lung Bi syndrome

lung Wei（ atrophy

痿） syndrome and other diseases.With Xuanfu（ 玄府） theory as a guide

this article systematically elaborates the relationship between Xuanfu and SSc

and raises that the main pathogenesis of the diseases caused by Xuanfu disorder can be summed up as 1) Qi diffusion and flow disorder

2) impairment of fluid distribution

3) blood stasis obstruction and 4) disfunction of the spirit. From the perspective of opening Xuanfu

the treatment for SSc can be divided into 2 types

including 1) directly opening Xuanfu method mainly by acrid Chinese herbs and 2) indirectly opening Xuanfu method mainly by unblocking Chinese herbs

thus analyzing the importance of Xuanfu and the method of opening Xuanfu in the treatment as the guidance of clinical practice.