Effect of Modified Guizhi Fuling Tang(桂枝茯苓汤) on Pulse Pressure and Hematocrit in Elderly Patients with Essential Hypertension with Blood Stasis Syndrome
WU Li, CHEN Jihong, GE Danxia, et al. Effect of Modified Guizhi Fuling Tang(桂枝茯苓汤) on Pulse Pressure and Hematocrit in Elderly Patients with Essential Hypertension with Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2018, 59(5): 402-405.
WU Li, CHEN Jihong, GE Danxia, et al. Effect of Modified Guizhi Fuling Tang(桂枝茯苓汤) on Pulse Pressure and Hematocrit in Elderly Patients with Essential Hypertension with Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2018, 59(5): 402-405.DOI: 10.13288/j.11-2166/r.2018.05.011.
Objective To discuss the effect of modified Guizhi Fuling Tang(桂枝茯苓汤
GFT) combined with conventional treatment in senile essential hypertension with blood stasis syndrome. Methods Sixty-eight elderly essential hypertension patients with blood stasis syndrome were randomized into a treatment group and a control group
with 34 cases in each. Both groups were treated with conventional western medicine perindopril tablets and hydrochlorothiazide tablets. Additionally
the treatment group was added with oral modified GFT
one dose a day
for 12 weeks. Before and after treatment
Chinese medicine symptom scores were measured to determine the efficacy of improving Chinese medicine syndromes; ambulatory blood pressure were tested
including 24 h mean systolic blood pressure(24-SBP)
24 h mean diastolic blood pressure(24-DBP)
nighttime mean systolic blood pressure(N-SBP)
nighttime mean diastolic blood pressure(N-DBP)
daytime mean systolic blood pressure(D-SBP) and daytime mean diastolic pressure(D-DBP)
to calculate the pulse pressure; and hematocrit was calculated. Results After treatment in the treatment group
20 cases were markedly effective
12 cases effective
2 cases ineffective
and 0 cases aggravated. The total effective rate was 95. 59%. In the control group
17 cases were markedly effective
10 effective
6 ineffective and 1 case aggravated. The total effective rate was 79. 41%. Effect of improving Chinese medicine syndrome in the treatment group was better than that in the control group(P < 0. 05). The 24-SBP
24-DBP
NSBP
D-SBP and D-DBP in the treatment group after treatment were significantly lower than those before treatment
and also significantly lower than those in the control group after treatment(P < 0. 05 or P < 0. 01). The pulse pressure and hematocrit after treatment were lower than those before treatment in each group
and the decrease in the treatment group was more obvious than that in the control group(P < 0. 05). Conclusion Modified GFT combined with conventional western medicine can reduce the pulse pressure and improve the hematocrit in elderly patients with essential hypertension with blood stasis syndrome
and its curative effect seems superior to that of conventional treatment alone.