Professor XIA Guicheng holds that premature ovarian insufficiency（POI） is owing to the dysfunction of heart-kidney-uterus axis and disharmony between heart and kidney. The cause of POI is deficiency of kidney-yin

gui-water（癸水） premature depletion

while it is closely related to heart. POI onset is mostly due to patients’ chronic mental stress leading to disquieted heart-mind

flaring up of heart fire

heart-blood ying-yin hidden consuming.A long time

kidney-yin is more and more deficient

which cannot produce essence

transform marrow and nourish heart-mind. A vicious cycle leads to POI. Menstrual cycle rhythm regulation method should be combined

treating from heart and kidney. The first and important is to treat heart

clearing heart-fire

nourishing heart-yin to lower heart-fire first. "Heart tranquillization "could bring "kidney enrichment ". Intercourse between heart and kidney makes premature depletion tiangui（天癸） renascence

re-establish Yin-Yang balance of heart-kidney-uterus axis and restore normal reproductive endocrine

with normal menstruation

to treat the root.