Objective To evaluate the clinical effect of modified Shugan Xiaozhi Decoction（疏肝消脂方） combined with behavior intervention in treating nonalcoholic fatly liver disease（NAFLD） and to explore the feasibility of FibroScan technique in fatty liver diagnosis. Methods Eighty NAFLD patients were randomized into a treatment group（40 cases） and a control group（40 cases）. In addition to behavior intervention

the treatment group was given oral modified Shugan Xiaozhi Decoction 1 dose each day; the control group was given oral polyene phosphatidylcholine capsules 456 mg each time

3 times each day. The course was 24 weeks in both groups. Patients’ controlled attenuation parameter（CAP） and liver stiffness（E） were detected in both groups by FibroScan technique before and after treatment. Patients’ body mass index（BMI）

fasting blood-glucose（FBG）

alanine aminotransferase（ALT）

Aspartate aminotransferase（AST）

γ-glutamyl transpeptidase（γ-GT）

total cholesterol（TC） and triglyceride（TG）in both groups were detected. Meanwhile

the difference of FibroScan and B-ultrasound in the diagnosis of fatty liver level was compared. Results Patients’ E

CAP

BMI

FBG

blood lipid and liver function in both groups were improved after treatment. The improvement in the treatment group was superior to that in the control group exceptγ-GT（P < 0. 05 or P < 0. 01）. There might be correlation between FibroScan technique and B-ultrasound in the diagnosis of fatty liver level

with poor consistency. Conclusion Modified Shugan Xiaozhi Decoction combined with behavior intervention might improve patients’ fatty infiltration of liver. FibroScan technique could be applied in noninvasive quantitative diagnosis of fatty liver.