Objective To evaluate the efficacy of Zishen Yisui Decoction（ 滋肾益髓方） as adjuvant therapy with Parkinson’ s Disease Chinese Medicine Quality of Life Scale（ draft）（ PD-QOL） in Parkinson’ s disease（ PD） of marrow-reservoir deficiency type. Methods Sixty cases of PD patients of marrow sea deficiency type were randomized into treatment group and control group

30 cases in each group. Both groups were given anti-PD western medicine treatment

while the treatment group was also treated with Zishen Yisui Decoction. Both groups were treated for 3 months. Before and after treatment

PD-QOL total score

and scores of dimension I and II（ PD-QOL-Ⅰ

PD-QOL-Ⅱ） were assessed

so were the Parkinson’s Disease Comprehensive Rating Scale（ UPDRS） total score

and Dimensions II and III（ UPDRS-Ⅱ

III） scores. The correlations between PD-QOL-Ⅰ

PD-QOL-Ⅱ and PD-QOL total scores and UPDRS-Ⅱ

UPDRS-Ⅲ and UPDRS total scores were analyzed before and after treatment. Results After treatment

in the treatment group

PD-QOL total score

PD-QOL-Ⅰ and PD-QOL-Ⅱ scores

UPDRS total score

UPDRS-Ⅱ and UPDRS-Ⅲ scores decreased after treatment（ P < 0. 05 or P < 0. 01）; the PD-QOL total score

PD-QOL-Ⅰ and PD-QOL-Ⅱ scores

UPDRS total score and UPDRS-Ⅱ score were lower than those in the control group（ P < 0. 05 or P < 0. 01）. Before treatment

there was no significant correlation between UPDRS-Ⅰ and PDQOL total score

PD-QOL-Ⅰ

PD-QOL-Ⅱ

between UPDRS-Ⅱ and UPDRS total score（ P > 0. 05）

while all other indicators had positive correlations（ P < 0. 05）. After treatment

there was no significant correlation between PDQOL-Ⅱ and UPDRS-Ⅰ

between UPDRS-Ⅱ and UPDRS total score（ P > 0. 05）

while all other indicators showed positive correlations（ P < 0. 05）. Conclusion As an adjuvant therapy

Zishen Yisui Decoction could improve the quality of life of PD patients.