Heshouwu（Polygoni Multiflori Radix） has always been considered as beneficial in enriching and nourishing the liver and kidney

but it received much concern due to its increasing liver injury reports in recent years.Heshouwu has toxicity records since ancient times. In recent years

the toxicity reports of Heshouwu were accidental immunospecific liver injury

and clinical irrational drug use is one of the main causes of hepatic injury. Heshouwu is warm in Qi

and not cold nor dry in property

with characteristics of"Yang herbs in Yin". The liver injury caused by Heshouwu was mainly seen in immune abnormal activation diseases

which belongs to hyperactivity of fire due to Yin deficiency

internal accumulation of heat toxin syndrome by Chinese medicine syndrome differentiation. It was proposed that Heshouwu could be used in blood deficiency syndrome with essence and blood depletion. Patients with hyperactivity of fire due to Yin deficiency

internal accumulation of heat toxin should be cautious with Heshouwu alone

instead supplementing Yin herbs should be used. The liver injury by Heshouwu can be reduced from medication with syndrome differentiation

and reasonable medication.