Objective To explore the regularity of food and medicine contraindication in the ancient Chinese prescription literatures. Methods The prescriptions relevant to food contraindication in ancient prescription literatures were collected and organized to analyze the relations between drugs

diseases and food contraindication by using the methods of association rules. Results 2587 prescriptions containing food and medicine contraindication after administration of herbal decoction from 39 ancient prescription literatures were collected. The higher frequency food prohibited included pork

green onion

cabbage etc.

which also had close relations with other food and medicinals.The highest frequency prohibited food pair was sargassum-cabbage

while the highest frequency food-medicinal pair was Gancao（ glycyrrhizae radix et rhizome）-sargassum. Wind disease is the most common disease syndrome

which normally contraindicated pork

raw or cold food

seaweed

etc. Cough and asthma was contraindicated seaweed

sargassum

green onion

etc. Malaria was contraindicated greed onion

cabbage

hot food

etc. Dysentery was usually contraindicated greasy

raw and cold

hot food

etc. Consumptive thirst syndrome was contraindicated pork

Wuyi（ fructus ulmi）

seaweed

etc. Edema was contraindicated salty

raw and cold food

vinegar

etc. Conclusion Food and medicine contraindication is an important content of the prescription notes. Medicinal-food and medicinalsyndrome contraindication are co-existing

which has a close relationship with seven emotions of Chinese herbs.Research and master of food and Chinese herb contraindication theory would provide objective basis for the prescription normalization and valuable support for ensuring clinical effects of traditional Chinese medicine.