Objective To observe the clinical effectiveness of Yiqi Hexue Formula（ Benefiting qi and harmonizing blood formula

益气和血方） combined with entecavir tablet on hepatitis B virus（ HBV） induced liver cirrhosis of decompensated stage. Methods Thirty-five patients with HBV induced liver cirrhosis of decompensated stage with qi deficiency and blood stasis syndrome were collected

and treated with modified Yiqi Hexue Formula combined with entecavir tablet for 24 months. The Chinese medicine syndrome integral

the elasticity value of the liver

size of the spleen

and width of portal vein were compared before and 3

6

12

24 months after treatment. Chinese medicine syndrome efficacy after treatment was observed. Results（ 1） Chinese medicine syndrome efficacy: 1 case was cured（ 2. 9%）

25 cases showed obvious efficacy（ 71. 4%）

4 cases showed efficacy（ 11. 4%）

and 5 cases showed no efficacy（ 14. 2%）

with 71 total number of effectiveness（ 85. 7%）. Symptom integral and width of portal vein at 3

6

12

24 months after treatment were all significantly decreased compared with that before treatment（ P <0. 01）. The elasticity of the liver

thickness of the spleen at 6

12

24 months after treatment were significantly decreased compare with before treatment(（ P < 0. 05 or P < 0. 01）. The length of the spleen after 12 and 24 months’ treatment was significantly decreased compared with before treatment（ P < 0. 01）. Conclusion Yiqi Hexue Formula combined with entecavir tablet can improve Chinese medicine syndrome integral of patients with HBV induced liver cirrhosis of decompensated stage

decrease elasticity of the liver

shorten the size of the spleen

decrease the width of portal vein

so as to slow the progress of liver cirrhosis.