Objective To observe the clinical effect of Liqi Huatan Kaiyu Decoction（ 理气化痰开郁方） combined with acupoint application on nonalcoholic fatty liver disease. Methods A hundred patients with nonalcoholic fatty liver disease with liver depression and spleen deficiency were randomly divided into treatment group（ 50 cases） and control group（ 50 cases）. The treatment group was treated with oral administration of Liqi Huatan Kaiyu Decoction and acupoint application. The control group was treated with oral silymarin capsule. All patients were treated for 3 months. Before and after treatment

the TCM syndrome scores and liver function indexes（ including serum alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST）

glutamyl transpeptidase（ GGT））

and lipids（ triglycerides（ TG）

total cholesterol（ TC）） of two groups were observed. After treatment

Chinese medicine syndrome efficacy was evaluated. Results The total effective rate of Chinese medicine syndrome in the treatment group（ 89. 58%） was higher than that in the control group（ 69. 05%）（ P < 0. 05）. After treatment

the symptom scores and total scores of the TCM patients in the treatment group were significantly lower（ P < 0. 01）. The fatigue

flank pain

and total scores were significantly lower in the control group after treatment than before treatment（ P < 0. 05）.After treatment in the two groups

the fatigue

flank pain

poor appetite

and total scores were lower in the treatment group than in the control group（ P < 0. 05）. After treatment

the ALT

AST

TC

and TG in both groups were significantly lower than before treatment（ P < 0. 05）. After treatment in the two groups

the ALT and TG in the treatment group were significantly lower than those in the control group（ P < 0. 05 or P < 0. 01）. Conclusion The clinical effectiveness of Liqi Huatan Kaiyu Decoction combined with acupoint application in the treatment of non-alcoholic fatty liver disease with liver depression and spleen deficiency is significantly better than that of silymarin Capsule.