Objective To evaluate the efficacy and possible mechanisms of preventing the inflammatory reaction and the early acute renal injury by using Baoshen Tablets（ 保 肾片） in patients underwent coronary angiography.Methods A total of 80 patients with coronary artery disease who underwent percutaneous coronary interventions（ PCI） were selected in this study. All subjects were randomly divided into treatment group（ 40 cases

coronary artery operation + routine treatment + Baoshen Tablets） and control group（ 40 cases

coronary artery operation + routine treatment）. The serum creatine（ Scr） and inflammatory factors including hypersensitive C-reactive protein（ hsCRP）

tumor necrosis factor-α（ TNF-α）

interleukin-6（ IL-6） 、interleukin-8（ IL-8） were recorded and compared at pre-operation

24 h and 72 h after PCI operation in both groups. Result Based on the contrasting analysis among two different groups

at 24 hours after PCI treatment

the levels of TNF-α、IL-6、IL-8 in the treatment group were lower than those in the contrast group（ P < 0. 01 or P < 0. 05）. At 72 hours after PCI treatment

the levels of Scr

hs-CRP、IL-8 in the treatment group were lower than those in the contrast group（ P < 0. 01 or P < 0. 05）. After comparing in the treatment group

at 24 hours after PCI treatment

the level of hs-CRP was higher than that at pre-operation（ P < 0. 01）

and the level of TNF-α was lower than that at pre-operation（ P < 0. 05）. At 72 hours after PCI treatment

the levels of Scr、hs-CRP、IL-6、IL-8 t were all lower than those at pre-operation（ P < 0. 01 or P <0. 05）. After comparing in the contrast group

at 24 hours after PCI treatment

the levels of hs-CRP、TNF-α、IL-6、IL-8 were higher than those at pre-operation（ P < 0. 01 or P < 0. 05）. At 72 hours after PCI treatmen

the levels of SCr and hs-CRP were higher than those at pre-operation（ P < 0. 01 or P < 0. 05）. Conclusion The Baoshen Tablets can decrease the secretion of various proinflammatory cytokines

and reduce elevation of serum concentration. This specially formulated product has shown the protection and prothetic capability in for contrast-induced acute kidney injury.