Objective To explore the medication rule of traditional Chinese medicine（ TCM） in the treatment of diabetes mellitus complicated with coronary heart disease（ CHD）. Methods Literatures on TCM treatment of diabetes complicated CHD were searched in Chinese National Knowledge Infrastructure（ CNKI）

Wanfang database

VIP database（ VIP）

retrieve related articles from January 2000 to July 2017. The prescriptions of include literatures were collected to establish the database. The distribution of herbs

functions

properties and flavor were analyzed.The frequency analysis

cluster analysis and association rules analysis were conducted to high frequency herbs.Results Totally 95 related literatures were included

involving 114 prescriptions

17 kinds

115 herbs with 1167 times of frequency. The top 5 herbs were Danshen [Radix Salviae Miltiorrhizae]（ 74）

Huangqi [Radix Astragali seu Hedysari]（ 60）

Banxia [Rhizoma Pinelliae]（ 55）

Fuling [Poria]（ 53）

and Danggui [Radix Angelicae Sinensis]（ 52）; The top 3 kinds of herbs were tonifying deficiency herbs（ 299）

activating blood and resolving stasis herbs（ 230）

clearing heat herbs（ 133）; The properties of herbs were mainly warm（ 491） and cold（ 410）. The flavor of herbs was mainly sweet（ 650）

bitter（ 548）

and acrid（ 379）. Cluster analysis was performed for 21 herbs with over 20 frequencies

and 8 herb pairs and 3 cluster groups were obtained. Through correlation analysis

29 correlated rules of herb pairs and combinations were obtained. Conclusion Traditional Chinese medicine treatment of diabetic coronary heart disease is mainly used to supplement deficiency

clear heat

activate blood

resolve phlegm. The commonly used herbs are sweet and warm Huangqi

acrid and warm Banxia

bitter and cold Danshen and Honghua [Flos Carthami].