Objective To observe the therapeutic effects of Fufang Tongluo Decoction（复方通络饮） in treatment of acute cerebral infarction and its possible mechanism. Methods A total of 158 patients with acute cerebral infarction were randomly divided treatment group（86 cases） and control group（72 cases）. The control group was given western medicine basic treatment

and the treatment group was added Fufang Tongluo Decoction

1 dose per day.Both groups were treated for 28 days. Before and 14

28 days after treatment

NIH Stroke Scale（NIHSS） and Barthel index were performed. The serum vascular endothelial growth factor（VEGF）

angiogenin 1（Ang-1）

basic fibroblast growth factor（b FGF） were detected. Results Compared with before treatment

the NIHSS scores decreased and the BI index increased after 14 and 28 days of treatment. The NIHSS scores of the treatment group were lower than those of the control group after 14 and 28 days of treatment

and the BI index was higher than that of the control group（P < 0. 05 or P < 0. 01）. Serum VEGF and Ang-1 levels in the treatment group were higher than those in the treatment group before treatment and the control group after treament. The serum b FGF content was lower than that before treatment within group and the control group after treatment（P < 0. 05 or P < 0. 01）. Conclusion Fufang Tongluo Decoction can improve the neurological function and the activities of daily living in patients with acute cerebral infarction

which may be related to the regulation of the expression of vascular endothelial growth factors.