Objective To observe the clinical effects of oral administration of Huangqi Zeling Granule（黄芪泽苓颗粒） combined with navel paste of Zhushui Cream（逐水膏） in treating moderate and severe hepatitis B cirrhosis ascites. Methods A total of 96 cirrhotic ascites patients with moderate and severe hepatitis B were randomly divided into treatment group and control group

with 48 cases in each group. The patients in the control group were treated with western medicine routine treatment. The patients in the treatment group were added Huangqi Zeling Granules orally and Zhushui Cream on Shenque（CV8）. Both groups were treated for 8 weeks. The changes of clinical symptoms of two groups before and after treatment were observed. The liver function

and the levels of blood ammonia（AMON）

lipopolysaccharide（LPS）

endothelin-1（ET-1）

nitric oxide（NO） were detected. The color Doppler examination was used to detect ascites depth

portal diameter and spleen thickness. The incidence of complications and adverse reactions was recorded. The average number of ascites ultrafiltration treatment and the average hospitalization time were analyzed

and the clinical comprehensive effect was judged after treatment. Results The total effective rate was 93. 75%（45/48） in the treatment group and 72. 92%（35/48） in the control group

and the treatment group was obviously superior to the control group（P < 0. 05）; The liver function index of 2 groups were significantly improved. The AMON

LPS

ET-1 and NO levels were decreased. The depth of ascites and thickness of the spleen were also decreased

and the treatment group was superior to the control group（P < 0. 05）. The incidence of complications

digestive tract hemorrhage

hepatic encephalopathy and hepatorenal syndrome in the treatment group was12. 5%

2. 08%

4. 17% and 0 respectively

and that of the control group was 27. 08%

12. 5%

22. 92% and4. 17%

respectively. The treatment group was all lower than the control group（P < 0. 05）. The average number of ascites ultrafiltration treatment and the average hospitalization time in the treatment group were lower than the control group（P < 0. 05）. Conclusion Oral administration of Huangqi Zeling Granule and navel paste of Zhushui Cream in the treatment of moderate and sever hepatitis B cirrhosis ascites can accelerate the withdrawal of ascites

promote the recovery of liver function

and reduce the complications.