This paper aimed at understanding function of spleen from different perspectives of Chinese and western medicine and its important role in the occurrence

development and prognosis of acquired immunodeficiency syndrome（ AIDS） to provide ideas and methods for the prevention and treatment of AIDS by traditional Chinese medicine. Human immunodeficiency virus（ HIV） is not only different from the six climatic exopathogens

but also different from the pestilential qi. It has its own unique onset

transmission and prognosis rules. Deficiency has always been throughout the course of the disease

and the spleen is the key lesion organ of the disease. With the general condition of spleen deficiency

there is more attention needed to pay for protecting spleen

improving the immune function of patients

slowing down the progress of AIDS

and improving the quality of life in the treatment of AIDS.