Objective To evaluate the efficacy and safety of Yangyin Shuxin Decoction（ 养阴舒心方） in patients with heart failure of normal ejection fraction（ HFNEF）. Methods A total of 60 patients with HFNEF were randomly divided into test group and control group

with 30 patients in each group. Integrated treatment of Yangyin Shuxin Decoction and western medication treatment directed by current guideline for heart failure were applied in the test group for 2 weeks

while only the same western medication was given to the control group. After the treatment

the Minnesota Living with Heart Failure Questionnaire（ MLHF-Q） score and the traditional Chinese medicine（ TCM）symptom score

6-minute walk distance（ 6 WMD）

the cardiac ultrasound related indicators [the transmitral early peak velocity（ E）/early diastolic mitral annulus velocity（ e’） ] and brain natriuretic peptide（ BNP） were evaluated. The adverse reactions were observed. Results After treatment

the TCM symptom scores of the 2 groups were decreased compared with those before treatment（ P < 0. 05 or P < 0. 01）. The score of MLHF-Q score after treatment was significantly improved in the test group compared with the control group（ P < 0. 05 or P < 0. 01）. Improvements in TCM symptom scores（ P < 0. 05） and E/e’（ P < 0. 05） were both improved in the test group than those in the control group. There was no significant difference in the incidence of adverse events between groups（ P > 0. 05）.Conclusion Yangyin Shuxin Decoction could further improve the quality of life

symptoms and the diastolic function in patients with HFNEF on the basis of western medication

which has good safety.