Objective To explore the clinical features of acute ischemic stroke patients with the syndrome of phlegm-heat and fu-viscera excess. Methods A total of 265 acute ischemic stroke patients were selected and divided into the phlegm-heat and fu-viscera excess syndrome group（117 cases） and the non-phlegm-heat and fu-viscera excess syndrome group（148 cases）. Demographic data of 2 groups including gender

age

body mass index（BMI）

vital signs

time of onset

and current and past medical history were investigated

and disease diagnosis scores as well as National Institutes of Health Stroke Scale scores（NIHSS） were observed. The high-sensitivity C-reactive protein（hs-CRP）

interleukin-6（IL-6）

tumor necrosis factor（TNF）

total triiodothyronine（TT3）

total thyroxine（TT4）

free triiodo Thyrolysine（FT3）

free thyroxine（FT4）

thyroid stimulating hormone（TSH）

adrenocorticotropic hormone（ACTH）

cortisol（CORT）

plasma renin activity（PRA）

angiotensin Ⅱ（Ang Ⅱ）

aldosterone（ALD）

glycated hemoglobin（HbA1 c）

homocysteine（HCY）

lipoprotein a [LP（a） ]

neuron-specific enolase（NSE） were detected. The logistic regression analysis and gradient lifting decision tree（GBDT） algorithm methods were used for data mining. Results Compared with the non-phlegm-heat and fu-viscera excess syndrome group

patients in the phlegm-heat and fu-viscera excess syndrome group had higher level BMI

course of disease

systolic pressure

disease diagnosis scores

NIHSS scores and TT4

FT4

LP（a）（P < 0. 05

or P < 0. 01）. As to laboratory indexes

the FT3

ACTH

CORT and NSE scores were lower（P < 0. 05

or P < 0. 01） than those of the non-phlegmheat and fu-viscera excess syndrome group. Logistic regression analysis showed that the partial regression coefficients of NIHSS

FT3 and CORT and syndrome of phlegm-heat and fu-viscera excess were statistically significant（P < 0. 05 or P < 0. 01）. The GBDT results showed that CORT

BMI

FT3

and ACTH were important features of phlegm-heat and fu-viscera excess pattern. Conclusion In patients with acute ischemic stroke

the higher the NIHSS score is

the lower the FT3 and CORT levels are

and the more likely that the syndrome of phlegm-heat and fu-viscera excess will onset.