Objective To observe the clinical efficacy of Bushen Yixin Tablets（补肾益心片） combined with western medicine in the interference of treating hypertension and type 2 diabetes patients with early renal damage and kidney deficiency syndrome.Methods A total of 100 hypertension and type 2 diabetes patients with early renal damage and kidney deficiency syndrome were randomly assigned into a treatment and a control group

50 cases in each group.The controll group was given calcium antagonist（or + diuretic and beta blocker） + hypoglycemic agent.Bushen Yixin Tablets was additionally administered to the treatemtn group.The treatment course was 12 weeks for two groups.The blood pressure

glycosylated hemoglobin（HbA1 c）

urinary microalbumin（m ALB）

urinary albumin to creatinine ratio（ACR）

cystatin C（CysC）

low density lipoprotein cholesterin（LDL-C） and phospholipase A2（PLA2）

creatinine（Cr） were compared before and after treatment.And the evaluation of traditional Chinese medicine（TCM） single syndrome efficacy was conducted.Results Compared with before treatment

the PLA2

LDL-C

diastolic blood pressure and systolic blood pressure

CysC

m ALB and ACR were significantly decreased in the treatment group（P<0.05）

and the LDL-C

CysC

m ALB and ACR were decreased more significantly in the treatment group than in the control group（P<0.05）.There were significant differences in the efficacy of TCM single syndrome between the groups（P<0.05）

and the treatment group was superior to the control group.Conclusion Bushen Yixin Tablets has function of protecting heart and kidney

and it can safely and effectively improve renal function and effective reduce cardiovascular risk.